BDBM455776 N-[[6-(2,2- dimethylcyclopropanecarbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide::US10730889, Example 371::US11485745, Example 373

SMILES CC1(C)CC1C(=O)N1CCC2(CC2CNC(=O)c2cc3ccncc3o2)CC1

InChI Key InChIKey=JHQOJIHIYZNJOC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 455776   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455776(N-[[6-(2,2- dimethylcyclopropanecarbonyl)- 6-azasp...)
Affinity DataIC50: 28.6nMAssay Description:NAMPT Protein Purification. Recombinant His-tagged NAMPT was produced in E. coli cells, purified over a Ni column, and further purified over a size-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
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TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455776(N-[[6-(2,2- dimethylcyclopropanecarbonyl)- 6-azasp...)
Affinity DataIC50: 28.6nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 17.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455776(N-[[6-(2,2- dimethylcyclopropanecarbonyl)- 6-azasp...)
Affinity DataIC50: 15.2nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 17.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent