BDBM455696 N-[[6-(2-phenoxyacetyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide::US10730889, Example 289::US11485745, Example 289

SMILES O=C(COc1ccccc1)N1CCC2(CC2CNC(=O)N2Cc3ccncc3C2)CC1

InChI Key InChIKey=RCCXDFMJLLJGPZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 455696   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455696(N-[[6-(2-phenoxyacetyl)-6- azaspiro[2.5]octan-2-yl...)
Affinity DataIC50: 9.99nMAssay Description:NAMPT Protein Purification. Recombinant His-tagged NAMPT was produced in E. coli cells, purified over a Ni column, and further purified over a size-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
Go to US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455696(N-[[6-(2-phenoxyacetyl)-6- azaspiro[2.5]octan-2-yl...)
Affinity DataIC50: 9.99nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 17.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent