BDBM455612 US10730889, Example 200::US11485745, Example 200::tert-butyl 2-[(1,3- dihydropyrrolo[3,4-c]pyridine-2- carbonylamino)methyl]-7- azaspiro[3.5]nonane-7- carboxylate

SMILES CC(C)(C)OC(=O)N1CCC2(CC(CNC(=O)N3Cc4ccncc4C3)C2)CC1

InChI Key InChIKey=BUWAOVDOQVREQS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 455612   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455612(US10730889, Example 200 | tert-butyl 2-[(1,3- dihy...)
Affinity DataIC50: 4.56nMAssay Description:NAMPT Protein Purification. Recombinant His-tagged NAMPT was produced in E. coli cells, purified over a Ni column, and further purified over a size-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
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TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455612(US10730889, Example 200 | tert-butyl 2-[(1,3- dihy...)
Affinity DataIC50: 4.56nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 17.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent