BDBM455007 US10730874, Compound I-31::US10730874, Compound I-61::US11352356, Compound I-31

SMILES COCc1nn(Cc2cn3cc(ccc3n2)C2CC2)cc1C(=O)NCc1ncn2ccc(Cl)cc12

InChI Key InChIKey=WNOWDWICFGNCLL-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 455007   

TargetPlasma kallikrein(Human)
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM455007(US10730874, Compound I-31 | US10730874, Compound I...)
Affinity DataEC50: <1nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM455007(US10730874, Compound I-31 | US10730874, Compound I...)
Affinity DataEC50:  5.5nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM455007(US10730874, Compound I-31 | US10730874, Compound I...)
Affinity DataEC50: <1nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent