BDBM454975 US10730870, Example 145

SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)c1cc(C)no1

InChI Key InChIKey=LIUCLKNTUXMZEI-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 454975   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 454975BDBM454975(US10730870, Example 145)
Affinity DataKd:  7nMAssay Description:Binding affinity to NanoLuc-fused VHL (unknown origin) transfected in live HEK293 cells using NanoGlo as substrate assessed as dissociation constant ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 454975BDBM454975(US10730870, Example 145)
Affinity DataIC50: 8nMAssay Description:Inhibition of NanoLuc-fused VHL (unknown origin) transfected in live HEK293 cells using NanoGlo as substrate incubated for 1 hrs by tracer based Nano...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed