BDBM454843 US10730870, Example 110::US10730870, Example 6::US11512083, Example 6

SMILES CC(C)[C@H](N1Cc2ccccc2C1=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C

InChI Key InChIKey=HEDFFPYRFJKXQP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 454843   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454843(US10730870, Example 6 | US10730870, Example 110 | ...)
Affinity DataIC50: 6.37E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454843(US10730870, Example 6 | US10730870, Example 110 | ...)
Affinity DataIC50: 697nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454843(US10730870, Example 6 | US10730870, Example 110 | ...)
Affinity DataIC50: 1.48E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454843(US10730870, Example 6 | US10730870, Example 110 | ...)
Affinity DataIC50: 2.16E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454843(US10730870, Example 6 | US10730870, Example 110 | ...)
Affinity DataIC50: 6.37E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454843(US10730870, Example 6 | US10730870, Example 110 | ...)
Affinity DataIC50: 697nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454843(US10730870, Example 6 | US10730870, Example 110 | ...)
Affinity DataIC50: 1.48E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent