BDBM454531 US10730860, TABLE 1.1

SMILES CC(C)(C)NS(=O)(=O)c1cccc(Nc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2N)c1

InChI Key InChIKey=ZPCCUWVIQCBBRF-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 454531   

TargetBromodomain-containing protein 4(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM454531(US10730860, TABLE 1.1)
Affinity DataIC50: 1.98E+3nMAssay Description:Assays were performed with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were diluted in 50 mM HEPES, 150...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
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TargetBromodomain-containing protein 4(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM454531(US10730860, TABLE 1.1)
Affinity DataKd:  483nMAssay Description:ITC was performed using a ITC200 microcalorimeter from GE (Northampton, Mass.). All experiments were carried out at 25° C. while stirring at 1000 rpm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent