BDBM454459 US10717742, Example Ib-189::US10717742, Example Ib-190::US10882866, Example Ib-190

SMILES Cc1c(ccc2n3C[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)c3nc12)C(O)=O

InChI Key InChIKey=JANVYBFCTRMKJM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 454459   

TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM454459(US10717742, Example Ib-189 | US10717742, Example I...)
Affinity DataIC50: 3nMAssay Description:15 μL of compound in 20% DMSO (serial pre-dilutions of compound are done in 100% DMSO) is pipetted to the wells of a white OptiPlate-96 (Perkin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM454459(US10717742, Example Ib-189 | US10717742, Example I...)
Affinity DataIC50: 2nMAssay Description:15 μL of compound in 20% DMSO (serial pre-dilutions of compound are done in 100% DMSO) is pipetted to the wells of a white OptiPlate-96 (Perkin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM454459(US10717742, Example Ib-189 | US10717742, Example I...)
Affinity DataIC50: 3nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM454459(US10717742, Example Ib-189 | US10717742, Example I...)
Affinity DataIC50: 2nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent