BDBM454378 US10717742, Example Ia-34::US10882866, Example Ia-34

SMILES Cc1c(ccc2c1nn3c2C[C@H]4[C@@H]3[C@@H]([C@]5(N4CC6CC6)c7ccc(cc7NC5=O)Cl)c8cccc(c8F)Cl)C(=O)O

InChI Key InChIKey=AMTXDBGKYPDTTA-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 454378   

TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM454378(US10717742, Example Ia-34 | US10882866, Example Ia...)
Affinity DataIC50: 2nMAssay Description:15 μL of compound in 20% DMSO (serial pre-dilutions of compound are done in 100% DMSO) is pipetted to the wells of a white OptiPlate-96 (Perkin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM454378(US10717742, Example Ia-34 | US10882866, Example Ia...)
Affinity DataIC50: 2nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM454378(US10717742, Example Ia-34 | US10882866, Example Ia...)
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)