BDBM454240 US10717733, Compound 33::US11098045, Compound 33::ethyl (Z)-3-(1-(4-amino-2-fluorobut-2-en- 1-yl)-5-(N,N-dimethylsulfamoyl)-2- methyl-1H-indol-3-yl)benzoate

SMILES CCOC(=O)c1cccc(c1)-c1c(C)n(C\C(F)=C\CN)c2ccc(cc12)S(=O)(=O)N(C)C

InChI Key InChIKey=NXNSCGDXGSAYPX-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 454240   

TargetOxidized low-density lipoprotein receptor 1(Bovine)
Pharmaxis

US Patent
LigandPNGBDBM454240(ethyl (Z)-3-(1-(4-amino-2-fluorobut-2-en- 1-yl)-5-...)
Affinity DataIC50: 300nMAssay Description:LOX and LOXL2: Lysyl oxidase (LOX) is an extracellular copper dependent enzyme which oxidizes peptidyl lysine and hydroxylysine residues in collagen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmaxis

US Patent
LigandPNGBDBM454240(ethyl (Z)-3-(1-(4-amino-2-fluorobut-2-en- 1-yl)-5-...)
Affinity DataIC50: 300nMAssay Description:LOX and LOXL2: Lysyl oxidase (LOX) is an extracellular copper dependent enzyme which oxidizes peptidyl lysine and hydroxylysine residues in collagen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetAmine oxidase [copper-containing] 3(Human)
Pharmaxis

US Patent
LigandPNGBDBM454240(ethyl (Z)-3-(1-(4-amino-2-fluorobut-2-en- 1-yl)-5-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Human recombinant SSAO/VAP-1 amine oxidase activity was determined using the coupled colorimetric method as described for monoamine oxidase, copper-c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Pharmaxis

US Patent
LigandPNGBDBM454240(ethyl (Z)-3-(1-(4-amino-2-fluorobut-2-en- 1-yl)-5-...)
Affinity DataIC50: 3.00E+3nMAssay Description:MAO-B: The specificity of the compounds of this invention was tested by determining their ability to inhibit MAO-B activities in vitro. Recombinant h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetOxidized low-density lipoprotein receptor 1(Bovine)
Pharmaxis

US Patent
LigandPNGBDBM454240(ethyl (Z)-3-(1-(4-amino-2-fluorobut-2-en- 1-yl)-5-...)
Affinity DataIC50: 300nMAssay Description:LOX: The assay was developed using either 384 or 96 well format. Briefly, in a standard 384 well plate assay 25 μL of a dilution of any of the i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmaxis

US Patent
LigandPNGBDBM454240(ethyl (Z)-3-(1-(4-amino-2-fluorobut-2-en- 1-yl)-5-...)
Affinity DataIC50: 300nMAssay Description:LOX: The assay was developed using either 384 or 96 well format. Briefly, in a standard 384 well plate assay 25 μL of a dilution of any of the i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent

TargetAmine oxidase [copper-containing] 3(Human)
Pharmaxis

US Patent
LigandPNGBDBM454240(ethyl (Z)-3-(1-(4-amino-2-fluorobut-2-en- 1-yl)-5-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Human recombinant SSAO/VAP-1 amine oxidase activity was determined using the coupled colorimetric method as described for monoamine oxidase, copper-c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Pharmaxis

US Patent
LigandPNGBDBM454240(ethyl (Z)-3-(1-(4-amino-2-fluorobut-2-en- 1-yl)-5-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Mao-B: The specificity of the compounds of this invention was tested by determining their ability to inhibit MAO-B activities in vitro. Recombinant h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
Go to US Patent