BDBM453717 US10730853, Compound XVI::US11420955, Compound XVI

SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OC2CCN(CC2)C2CCCC2)cc1)S(F)(F)(F)(F)F

InChI Key InChIKey=AAZBNPTVFZEWKG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 453717   

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM453717(US10730853, Compound XVI | US11420955, Compound XV...)
Affinity DataIC50: 175nMAssay Description:Materials: GTPγS, [35S] (PerkinElmer, Cat # NEG030H001MC), DMSO (Amresco, Cat #0231), MicroScint™-20 (PerkinElmer, Cat #6013621), CelLytic&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM453717(US10730853, Compound XVI | US11420955, Compound XV...)
Affinity DataIC50: 116nMAssay Description:Materials: GTPγS, [35S] (PerkinElmer, Cat # NEG030H001MC), DMSO (Amresco, Cat #0231), MicroScint™-20 (PerkinElmer, Cat #6013621), CelLytic&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM453717(US10730853, Compound XVI | US11420955, Compound XV...)
Affinity DataIC50: 175nMAssay Description:Experimental procedure: 1) Membrane preparation for HEK293/Ga15/hH3R; 2) Standard binding assay. Briefly, for membrane parathion, HEK293/Ga15/hH3R ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM453717(US10730853, Compound XVI | US11420955, Compound XV...)
Affinity DataIC50: 116nMAssay Description:Experimental procedure: 1) Membrane preparation for HEK293/Ga15/hH3R; 2) Standard binding assay. Briefly, for membrane parathion, HEK293/Ga15/hH3R ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent