BDBM453391 3-{6-[2-(1-Naphthyl)ethoxy]-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl}cyclobutanecarboxylic Acid::US10730830, Example 23 (8)::US10730830, Example 3 (5)

SMILES OC(=O)C1CN(C1)C1CCc2c(C1)cccc2OCCc1cccc2ccccc12

InChI Key InChIKey=QHGLPIDHYXMVGR-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 453391   

TargetSphingosine 1-phosphate receptor 5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM453391(US10730830, Example 23 (8) | 3-{6-[2-(1-Naphthyl)e...)
Affinity DataIC50: 50nMAssay Description:Compound of the Present Invention on Binding of [33P]-S1P to S1P5 (EDG-8)A reaction was carried out in a 96-well microplate by using membrane fractio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM453391(US10730830, Example 23 (8) | 3-{6-[2-(1-Naphthyl)e...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the Present Invention on Binding of [33P]-S1P to S1P5 (EDG-8)A reaction was carried out in a 96-well microplate by using membrane fractio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM453391(US10730830, Example 23 (8) | 3-{6-[2-(1-Naphthyl)e...)
Affinity DataEC50:  50nMAssay Description:CHO cells which were made to overexpress human S1P5 (EDG-8) gene were cultured in Ham's F12 Medium (manufactured by Gibco-BRL) containing 10% FBS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent