BDBM453381 1-[5-({(2E)-3-[4-(Trifluoromethyl)phenyl]-2-propen-1-yl}oxy)-1,2,3,4-tetrahydro-2-naphthalenyl]-3-pyrrolidinecarboxylic Acid::US10730830, Example 3 (1)

SMILES OC(=O)C1CCN(C1)C1CCc2c(C1)cccc2OC\C=C\c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=VIVVGOBQTUHDIU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 453381   

TargetSphingosine 1-phosphate receptor 5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM453381(1-[5-({(2E)-3-[4-(Trifluoromethyl)phenyl]-2-propen...)
Affinity DataIC50: 2.00E+3nMAssay Description:Compound of the Present Invention on Binding of [33P]-S1P to S1P5 (EDG-8)A reaction was carried out in a 96-well microplate by using membrane fractio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
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TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM453381(1-[5-({(2E)-3-[4-(Trifluoromethyl)phenyl]-2-propen...)
Affinity DataIC50: 3.00E+4nMAssay Description:Compound of the Present Invention on Binding of [33P]-S1P to S1P5 (EDG-8)A reaction was carried out in a 96-well microplate by using membrane fractio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent