BDBM453312 BDBM453343::BDBM553818::US10730826, Compound 12a

SMILES NCCCCC(NC(=O)c1cccc(c1)N=[N+]=[N-])C(=O)COc1c(F)cccc1F

InChI Key InChIKey=GHJYTGRJHFYHNA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 453312   

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453312(BDBM553818 | BDBM453343 | US10730826, Compound 12a)
Affinity DataIC50: 0.0800nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453312(BDBM553818 | BDBM453343 | US10730826, Compound 12a)
Affinity DataIC50: 0.0800nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453312(BDBM553818 | BDBM453343 | US10730826, Compound 12a)
Affinity DataIC50: 0.0800nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453312(BDBM553818 | BDBM453343 | US10730826, Compound 12a)
Affinity DataIC50: 0.0800nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent