BDBM453308 US10730826, Compound 8a::US11325884, Compound 8a

SMILES NCCCCC(NC(=O)C1CCCC1)C(=O)COc1cc(F)cc(F)c1

InChI Key InChIKey=YVQMMISELLTZSJ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 453308   

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453308(US10730826, Compound 8a | US11325884, Compound 8a)
Affinity DataIC50: 0.340nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
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TargetCathepsin B(Human)
Cortexyme

US Patent
LigandPNGBDBM453308(US10730826, Compound 8a | US11325884, Compound 8a)
Affinity DataIC50: 6.83E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Cortexyme

US Patent
LigandPNGBDBM453308(US10730826, Compound 8a | US11325884, Compound 8a)
Affinity DataIC50: 1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin K(Human)
Cortexyme

US Patent
LigandPNGBDBM453308(US10730826, Compound 8a | US11325884, Compound 8a)
Affinity DataIC50: 1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Cortexyme

US Patent
LigandPNGBDBM453308(US10730826, Compound 8a | US11325884, Compound 8a)
Affinity DataIC50: 1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453308(US10730826, Compound 8a | US11325884, Compound 8a)
Affinity DataIC50: 0.340nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin B(Human)
Cortexyme

US Patent
LigandPNGBDBM453308(US10730826, Compound 8a | US11325884, Compound 8a)
Affinity DataIC50: 6.83E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Cortexyme

US Patent
LigandPNGBDBM453308(US10730826, Compound 8a | US11325884, Compound 8a)
Affinity DataIC50: 1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin K(Human)
Cortexyme

US Patent
LigandPNGBDBM453308(US10730826, Compound 8a | US11325884, Compound 8a)
Affinity DataIC50: 1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Cortexyme

US Patent
LigandPNGBDBM453308(US10730826, Compound 8a | US11325884, Compound 8a)
Affinity DataIC50: 1.00E+5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent