BDBM453307 US10730826, Compound 7a::US11325884, Compound 7a

SMILES NCCCCC(NC(=O)C1CCCC1)C(=O)COc1cccc(F)c1

InChI Key InChIKey=OXENNQILLFXVQW-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 453307   

TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.30nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin B(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin K(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.30nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 5.53E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin K(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 2.02E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 2.41E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin B(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 4.96E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.30nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin B(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin K(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 1.30nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 5.53E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin K(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 2.02E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 2.41E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin B(Human)
Cortexyme

US Patent
LigandPNGBDBM453307(US10730826, Compound 7a | US11325884, Compound 7a)
Affinity DataIC50: 4.96E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent