BDBM453215 1-(4-(((1R)-3,3-difluorocyclohexyl)ethynyl)-5-fluoro- 2-methoxyphenyl)-N-3-isoxazolyl-2-oxo-1,2-dihydro- 6-quinolinesulfonamide, 1-(4-(((1S)-3,3- difluorocyclohexyl)ethynyl)-5-fluoro-2- methoxyphenyl)-N-3-isoxazolyl-2-oxo-1,2-dihydro-6- quinolinesulfonamide::US10729684, Example 8

SMILES COc1cc(C#CC2(CCCC2)OCC(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1

InChI Key InChIKey=GVOUGZZOOUYAFJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 453215   

LigandPNGBDBM453215(1-(4-(((1R)-3,3-difluorocyclohexyl)ethynyl)-5-fluo...)
Affinity DataIC50: 9.73nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
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LigandPNGBDBM453215(1-(4-(((1R)-3,3-difluorocyclohexyl)ethynyl)-5-fluo...)
Affinity DataIC50: 33.8nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent