BDBM453214 1-(5-chloro-4-(cyclopentylethynyl)-2- methoxyphenyl)-N-3-isoxazolyl-2-oxo-1,2-dihydro-6- quinolinesulfonamide::US10729684, Example 7

SMILES COc1cc(C#C[C@@H]2CCCC(F)(F)C2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1

InChI Key InChIKey=COTOEAAIYPNKMO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 453214   

LigandPNGBDBM453214(1-(5-chloro-4-(cyclopentylethynyl)-2- methoxypheny...)
Affinity DataIC50: 7.80nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated elec...More data for this Ligand-Target Pair
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Date in BDB:
3/21/2021
Entry Details
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LigandPNGBDBM453214(1-(5-chloro-4-(cyclopentylethynyl)-2- methoxypheny...)
Affinity DataIC50: 66.7nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent