BDBM453210 1-(5-fluoro-2-methoxy-4-(((1R,2S)-2- (trifluoromethyl)cyclopropyl)ethynyl)phenyl)-N-3- isoxazolyl-2-oxo-1,2-dihydro-6- quinolinesulfonamide, 1-(5-fluoro-2-methoxy-4- (((1S,2S)-2- (trifluoromethyl)cyclopropyl)ethynyl)phenyl)-N-3- isoxazolyl-2-oxo-1,2-dihydro-6-quinolinesulfonamide::US10729684, Example 4A

SMILES COc1cc(C#C[C@H]2C[C@@H]2C(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1

InChI Key InChIKey=SETQALMDUPPLPZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 453210   

LigandPNGBDBM453210(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2- (trifluoromet...)
Affinity DataIC50: 6.80nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

LigandPNGBDBM453210(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2- (trifluoromet...)
Affinity DataIC50: 210nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent