BDBM453208 1-(4-(cyclopentylethynyl)-2-methoxyphenyl)-N-3- isoxazolyl-2-oxo-1,2-dihydro-6-quinolinesulfonamide::US10729684, Example 3

SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)C#CC1CCCC1

InChI Key InChIKey=XXPURYURKWMTTC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 453208   

LigandPNGBDBM453208(1-(4-(cyclopentylethynyl)-2-methoxyphenyl)-N-3- is...)
Affinity DataIC50: 7.5nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
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LigandPNGBDBM453208(1-(4-(cyclopentylethynyl)-2-methoxyphenyl)-N-3- is...)
Affinity DataIC50: 49.7nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent