BDBM452996 (1R,2S,3R,5S)-3-(4-amino- 7H-pyrrolo[2,3-d]pyrimidin-7- yl)-5-((S)-5-chloro-1,3- dihydroisobenzofuran-1- yl)cyclopentane-1,2-diol::US10711007, Example 2B::US11214574, Ex# 2B::US11254683, Example 2B

SMILES Nc1ncnc2n(ccc12)[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)[C@@H]1OCc2cc(Cl)ccc12

InChI Key InChIKey=SSNBXGFUCGOVPH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 452996   

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM452996((1R,2S,3R,5S)-3-(4-amino- 7H-pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 31nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM452996((1R,2S,3R,5S)-3-(4-amino- 7H-pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 31nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM452996((1R,2S,3R,5S)-3-(4-amino- 7H-pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50: 31nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2022
Entry Details
Go to US Patent