BDBM452760 7-methyl-1-[[3- [(1S,5S,6R)-3-(2- fluorophenyl)-6- bicyclo[3.1.0]hex-2- enyl]-1,2,4- oxadiazol-5-yl] methyl]purin-6-one::US10711004, Example 82::US10711004, Example 83

SMILES Cn1cnc2ncn(Cc3nc(no3)[C@H]3[C@@H]4CC(=C[C@H]34)c3ccccc3F)c(=O)c12

InChI Key InChIKey=NQEUZZGRELLFAS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 452760   

LigandPNGBDBM452760(US10711004, Example 82 | US10711004, Example 83 | ...)
Affinity DataIC50: 15.4nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
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LigandPNGBDBM452760(US10711004, Example 82 | US10711004, Example 83 | ...)
Affinity DataIC50: 8.5nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

LigandPNGBDBM452760(US10711004, Example 82 | US10711004, Example 83 | ...)
Affinity DataIC50: 12.7nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

LigandPNGBDBM452760(US10711004, Example 82 | US10711004, Example 83 | ...)
Affinity DataIC50: 4.70nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent