BDBM4522 4-Phenylamino-3-quinolinecarbonitrile deriv. 27::4-[(2,4-Dichlorophenyl)amino]-7-[3-(4-hydroxy-1-piperidinyl)propoxy]-6-methoxy-3-quinolinecarbonitrile::4-[(2,4-dichlorophenyl)amino]-7-[3-(4-hydroxypiperidin-1-yl)propoxy]-6-methoxyquinoline-3-carbonitrile

SMILES COc1cc2c(Nc3ccc(Cl)cc3Cl)c(cnc2cc1OCCCN1CCC(O)CC1)C#N

InChI Key InChIKey=QTHJACLOGHWLAX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4522   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4522(4-[(2,4-dichlorophenyl)amino]-7-[3-(4-hydroxypiper...)
Affinity DataIC50: 3.5nMAssay Description:Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2005
Entry Details Article
PubMed