BDBM451094 US10676485, Example 4

SMILES CN1CCN(C[C@@H]2COc3ccc(OCc4ccnc(n4)C4COCCO4)c(C[C@@H](Oc4ncnc5sc(c(-c6ccc(O2)c(Cl)c6C)c45)-c2ccc(F)cc2)C(O)=O)c3)CC1

InChI Key InChIKey=RMGYIYZORJNRLC-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 451094   

LigandPNGBDBM451094(US10676485, Example 4)
Affinity DataKi:  0.0550nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM451094(US10676485, Example 4)
Affinity DataKi:  0.320nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent