BDBM451074 8-(2,4-dimethylpyrimidin-5-yl)-1-(ethylsulfonyl)-::US10676479, Example 104

SMILES CCS(=O)(=O)c1ncn2c(NCc3c4CCOc4ccc3F)ncc(-c3cnc(C)nc3C)c12

InChI Key InChIKey=WJGTVLNQOSQGAG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451074   

LigandPNGBDBM451074(US10676479, Example 104 | 8-(2,4-dimethylpyrimidin...)
Affinity DataIC50: 3nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM451074(US10676479, Example 104 | 8-(2,4-dimethylpyrimidin...)
Affinity DataIC50: 10.5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM451074(US10676479, Example 104 | 8-(2,4-dimethylpyrimidin...)
Affinity DataIC50: 2.10nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent