BDBM451038 8-(4-((dimethylamino)methyl)phenyl)-N-(2-fluoro-::US10676479, Example 68

SMILES COc1cccc(F)c1CNc1ncc(-c2ccc(CN(C)C)cc2)c2cncn12

InChI Key InChIKey=RNSWYJXDGLPNBN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 451038   

LigandPNGBDBM451038(US10676479, Example 68 | 8-(4-((dimethylamino)meth...)
Affinity DataIC50: 201nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM451038(US10676479, Example 68 | 8-(4-((dimethylamino)meth...)
Affinity DataIC50: 246nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM451038(US10676479, Example 68 | 8-(4-((dimethylamino)meth...)
Affinity DataIC50: 0.100nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent