BDBM450597 N-[(3,4- Dichlorophenyl)methyl]-N- methyl-2-(4-oxo-6-piperidin-4- ylquinazolin-3-yl)acetamide (Example 165, step A) and 2- methyltetrahydrofuran-2- carboxylic acid ([CAS RN 61449-65-8])::US10676446, Example 181

SMILES CN(Cc1ccc(Cl)c(Cl)c1)C(=O)Cn1cnc2ccc(cc2c1=O)C1CCN(CC1)C(=O)C1(C)CCCO1

InChI Key InChIKey=XHLMVGZXIHDKSV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 450597   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM450597(US10676446, Example 181 | N-[(3,4- Dichlorophenyl)...)
Affinity DataIC50: 8nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
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Date in BDB:
3/10/2021
Entry Details
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