BDBM450463 9H-Fluoren-9-ylmethyl 4-[3-[2-[(3,4-dichloro- phenyl)methylamino]-2- oxoethyl]-4- oxoquinazolin-6-yl] piperazine-1- carboxylate (intermediate A-5) and 4-sulfamoylbutanoic acid ([CAS RN 175476-52-5])::US10676446, Example 72

SMILES c1cc(c(cc1CNC(=O)CN2C=Nc3ccc(cc3C2=O)N4CCN(CC4)C(=O)CCCS(=O)(=O)N)Cl)Cl

InChI Key InChIKey=PYOCFAOKLJFTGQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 450463   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM450463(US10676446, Example 72 | 9H-Fluoren-9-ylmethyl 4-[...)
Affinity DataIC50: 10nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
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Date in BDB:
3/10/2021
Entry Details
Go to US Patent