BDBM4491 1-(3-Chlorophenylamino)-6,7-dimethoxyisoquinoline-4-carbonitrile::1-[(3-chlorophenyl)amino]-6,7-dimethoxyisoquinoline-4-carbonitrile::6,7-dimethoxyisoquinoline-4-carbonitrile deriv. 62

SMILES COc1cc2c(Nc3cccc(Cl)c3)ncc(C#N)c2cc1OC

InChI Key InChIKey=FGOHOSIVNWPTCI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4491   

TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4491(1-(3-Chlorophenylamino)-6,7-dimethoxyisoquinoline-...)
Affinity DataIC50: 8.83E+4nMAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4491(1-(3-Chlorophenylamino)-6,7-dimethoxyisoquinoline-...)
Affinity DataIC50: 8.91E+4nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed