BDBM449046 US10702498, Compound 8::US11484525, Compound 8

SMILES CC(C)C(CNC(=O)c1ccc(s1)[N+]([O-])=O)N1CCc2ccccc2C1

InChI Key InChIKey=GYCJOMIBWJVPSS-UHFFFAOYSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 449046   

TargetTumor protein p53-inducible nuclear protein 2(Human)
University of California

US Patent
LigandPNGBDBM449046(US10702498, Compound 8 | US11484525, Compound 8)
Affinity DataEC50:  6.60E+3nMAssay Description:For a primary screen of selected molecules, binding to OR was assessed by measuring competition against the radioligand 3H-diprenorphine (3H-DPN). Ea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
University of California

US Patent
LigandPNGBDBM449046(US10702498, Compound 8 | US11484525, Compound 8)
Affinity DataKi:  460nMAssay Description:For a primary screen of selected molecules, binding to OR was assessed by measuring competition against the radioligand 3H-diprenorphine (3H-DPN). Ea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
University of California

US Patent
LigandPNGBDBM449046(US10702498, Compound 8 | US11484525, Compound 8)
Affinity DataKi:  460nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
University of California

US Patent
LigandPNGBDBM449046(US10702498, Compound 8 | US11484525, Compound 8)
Affinity DataKi:  820nMAssay Description:For a primary screen of selected molecules, binding to OR was assessed by measuring competition against the radioligand 3H-diprenorphine (3H-DPN). Ea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
University of California

US Patent
LigandPNGBDBM449046(US10702498, Compound 8 | US11484525, Compound 8)
Affinity DataKi:  820nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent