BDBM448631 6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1,3-dimethyl-4-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazol-2(3H)-one::US10696655, Example 97::US11168070, Example 97

SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc(C4CCOCC4)c4n(C)c(=O)n(C)c4c3)c2cc1C(F)F

InChI Key InChIKey=ACWYHOLHBZFNAR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448631   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM448631(US10696655, Example 97 | 6-(7-(difluoromethyl)-6-(...)
Affinity DataIC50: 4nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM448631(US10696655, Example 97 | 6-(7-(difluoromethyl)-6-(...)
Affinity DataIC50: 4nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent