BDBM448438 US10695347, Compound I-4::US10695347, Compound I-7

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccnc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCOCC1

InChI Key InChIKey=LLCBZKZOXTXLJH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 448438   

TargetALK tyrosine kinase receptor(Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

US Patent
LigandPNGBDBM448438(US10695347, Compound I-7 | US10695347, Compound I-...)
Affinity DataIC50: 5.5nMAssay Description:1× Kinase Buffer 50 mM HEPES. pH 7.5 0.0015% Brij-35 10 mM MgCl2 2 mM DTT 2) stop buffer 100 mM HEPES, pH 7.5 0.015% Brij-35 0.2% Coating Reagent #3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

US Patent
LigandPNGBDBM448438(US10695347, Compound I-7 | US10695347, Compound I-...)
Affinity DataIC50: 5.5nMAssay Description:1× Kinase Buffer 50 mM HEPES. pH 7.5 0.0015% Brij-35 10 mM MgCl2 2 mM DTT 2) stop buffer 100 mM HEPES, pH 7.5 0.015% Brij-35 0.2% Coating Reagent #3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

US Patent
LigandPNGBDBM448438(US10695347, Compound I-7 | US10695347, Compound I-...)
Affinity DataIC50: 5.5nMAssay Description:1× Kinase Buffer 50 mM HEPES. pH 7.5 0.0015% Brij-35 10 mM MgCl2 2 mM DTT 2) stop buffer 100 mM HEPES, pH 7.5 0.015% Brij-35 0.2% Coating Reagent #3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

US Patent
LigandPNGBDBM448438(US10695347, Compound I-7 | US10695347, Compound I-...)
Affinity DataIC50: 5.5nMAssay Description:1× Kinase Buffer 50 mM HEPES. pH 7.5 0.0015% Brij-35 10 mM MgCl2 2 mM DTT 2) stop buffer 100 mM HEPES, pH 7.5 0.015% Brij-35 0.2% Coating Reagent #3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent