BDBM448406 1-[(2-{3-Azabicyclo[3.1.0]hexan-3-yl}-4-methylpyrimidin-5-yl)methyl]-N-[(6R)-3-methyl-1H,4H,5H,6H- cyclopenta[c]pyrazol-6-yl]-1H-1,2,3-triazole-4-carboxamide::US10695334, Example 87

SMILES Cc1c2CC[C@@H](NC(=O)c3cn(Cc4cnc(nc4C)N4CC5CC5C4)nn3)c2nn1COCC[Si](C)(C)C

InChI Key InChIKey=LXWFSNVUCGMOGD-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448406   

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM448406(US10695334, Example 87 | 1-[(2-{3-Azabicyclo[3.1.0...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
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Date in BDB:
3/2/2021
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM448406(US10695334, Example 87 | 1-[(2-{3-Azabicyclo[3.1.0...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent