BDBM448402 1-[(6-{2-Azaspiro[3.31]heptan-2-yl}-2-methylpyridin-3-yl)methyl]-N-[(6R)-3-methyl-2H,4H,5H,6H- cyclopenta[c]pyrazol-6-yl]-1H-pyrazole-4-::US10695334, Example 54

SMILES Cc1c2CC[C@@H](NC(=O)c3cnn(Cc4ccc(F)nc4C)c3)c2nn1COCC[Si](C)(C)C

InChI Key InChIKey=BZOPKNBZYRMPLV-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448402   

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM448402(US10695334, Example 54 | 1-[(6-{2-Azaspiro[3.31]he...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
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Date in BDB:
3/2/2021
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM448402(US10695334, Example 54 | 1-[(6-{2-Azaspiro[3.31]he...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent