BDBM448398 1-{[6-(3,3-Difluoropyrrolidin-1-yl)-2-methylpyridin-3-yl]methyl}-N-[(6R)-3-methyl-2H,4H,5H,6H-::US10695334, Example 37

SMILES Cc1[nH]nc2[C@@H](CCc12)NC(=O)c1cnn(Cc2ccc(nc2C)N2CCC(F)(F)C2)c1

InChI Key InChIKey=XMRNPPRMAXFVDP-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448398   

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM448398(US10695334, Example 37 | 1-{[6-(3,3-Difluoropyrrol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM448398(US10695334, Example 37 | 1-{[6-(3,3-Difluoropyrrol...)
Affinity DataKi:  2nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent