BDBM448379 4-[(6-{3-Azabicyclo[3.1.0]hexan-3-yl}-2-methylpyridin-3-yl)methyl]-N-[(6R)-3-methyl-1H,4H,5H,6H- cyclopenta[c]pyrazol-6-yl]-1H-pyrrole-2-carboxamide::US10695334, Example 7

SMILES Cc1nc(ccc1Cc1cc(C(O)=O)n(COCC[Si](C)(C)C)c1)N1CC2CC2C1

InChI Key InChIKey=BPFQHQGUCMVTKA-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448379   

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM448379(US10695334, Example 7 | 4-[(6-{3-Azabicyclo[3.1.0]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
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Date in BDB:
3/2/2021
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM448379(US10695334, Example 7 | 4-[(6-{3-Azabicyclo[3.1.0]...)
Affinity DataKi:  0.700nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent