BDBM448290 US10689705, Compound 67

SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(OC4CCOCC4)cc3[nH]2)c1N

InChI Key InChIKey=FBKIPMHVNJQANW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 448290   

TargetFibroblast growth factor receptor 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM448290(US10689705, Compound 67)
Affinity DataIC50: 3nMAssay Description:The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM448290(US10689705, Compound 67)
Affinity DataIC50: 4.30nMAssay Description:The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM448290(US10689705, Compound 67)
Affinity DataIC50: 6.70nMAssay Description:The FGFR3 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent