BDBM448270 US10689705, Compound 47

SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCN(CC4)S(C)(=O)=O)ccc3[nH]2)c1N

InChI Key InChIKey=TUJGAAZZROOKNS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 448270   

TargetFibroblast growth factor receptor 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM448270(US10689705, Compound 47)
Affinity DataIC50: 7.90nMAssay Description:The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
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TargetFibroblast growth factor receptor 2(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM448270(US10689705, Compound 47)
Affinity DataIC50: 11nMAssay Description:The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM448270(US10689705, Compound 47)
Affinity DataIC50: 36nMAssay Description:The FGFR3 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent