BDBM446556 (S)- or (R) N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7-(4-fluorophenyl)-N4,5-dimethyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::US10669276, Example 46p

SMILES C[C@@H]1CN(c2nc(Nc3ccc(c(F)c3)-n3cnc(C)c3)nc(Cl)c12)c1ccc(F)cc1

InChI Key InChIKey=GKNMZBKPHYTRGF-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 446556   

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM446556((S)- or (R) N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1...)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
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