BDBM4465 6,7-Dimethoxy-4-(3-methylthiophenylamino)quinoline-3-carbonitrile Hydrochloride::6,7-dialkoxyquinoline-3-carbonitrile deriv. 28::6,7-dimethoxy-4-{[3-(methylsulfanyl)phenyl]amino}quinoline-3-carbonitrile

SMILES COc1cc2ncc(C#N)c(Nc3cccc(SC)c3)c2cc1OC

InChI Key InChIKey=ZSJDOQUXSFYFRM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4465   

TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4465(6,7-Dimethoxy-4-(3-methylthiophenylamino)quinoline...)
Affinity DataIC50: 760nMAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4465(6,7-Dimethoxy-4-(3-methylthiophenylamino)quinoline...)
Affinity DataIC50: 759nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed