BDBM446180 US10669268, Example 8.01

SMILES c1cc(ccc1/C=C/C(=O)N2CC[C@@H]3CN(C[C@@H]3CC2)C(=O)N4CCc5c(nn[nH]5)C4)OC(F)(F)F

InChI Key InChIKey=JCUYLNIOELOLJV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 446180   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM446180(US10669268, Example 8.01)
Affinity DataIC50: 2nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent