BDBM446141 US10669268, Example 12B::US10669268, Example 4.08::cis-3,5-dichlorobenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate

SMILES Clc1cc(Cl)cc(COC(=O)N2C[C@@H]3CCN(C[C@@H]3C2)C(=O)c2ccc3[nH]nnc3c2)c1

InChI Key InChIKey=JQDSZGNVNWMBLL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446141   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM446141(US10669268, Example 4.08 | cis-3,5-dichlorobenzyl ...)
Affinity DataIC50: 47nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM446141(US10669268, Example 4.08 | cis-3,5-dichlorobenzyl ...)
Affinity DataIC50: 5nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent