BDBM445801 US10669240, Compound 97

SMILES Cc1ncc(NC(=O)c2n[nH]c3ccc(cc23)-c2cccnc2)cn1

InChI Key InChIKey=FJQLBBOHMPVGMM-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 445801   

TargetProto-oncogene Wnt-1(Human)
Samumed

US Patent
LigandPNGBDBM445801(US10669240, Compound 97)
Affinity DataIC50: 100nMAssay Description:Reporter cell lines were generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a W...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
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LigandPNGBDBM445801(US10669240, Compound 97)
Affinity DataEC50:  556nMAssay Description:SH-SY5Y cells are cultured in DMEM/F-12 medium supplemented with 15% FBS, Non-essential Amino Acid and Penicillin/Streptamycin. Two days before treat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
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TargetPulmonary surfactant-associated protein A1(Human)
Samumed

US Patent
LigandPNGBDBM445801(US10669240, Compound 97)
Affinity DataIC50: 135nMAssay Description:Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 8-point dose-response curves f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent