BDBM4457 4-(4-Chloro-2-fluorophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile::4-Phenylamino-3-quinolinecarbonitrile deriv. 2r::4-[(4-chloro-2-fluorophenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile::6,7-dialkoxyquinoline-3-carbonitrile deriv. 20

SMILES COc1cc2ncc(C#N)c(Nc3ccc(Cl)cc3F)c2cc1OC

InChI Key InChIKey=AZGVCABJHURYHG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4457   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4457(4-Phenylamino-3-quinolinecarbonitrile deriv. 2r | ...)
Affinity DataIC50: 53nMAssay Description:Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4457(4-Phenylamino-3-quinolinecarbonitrile deriv. 2r | ...)
Affinity DataIC50: 1.39E+4nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4457(4-Phenylamino-3-quinolinecarbonitrile deriv. 2r | ...)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed