BDBM445689 Ex. 25/KM-06-113/(I-25)::US10683309, Example 25::US11028104, Example 25

SMILES CCCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O

InChI Key InChIKey=GOHNCSPZIXYWEG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 445689   

TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandPNGBDBM445689(Ex. 25/KM-06-113/(I-25) | US10683309, Example 25 |...)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandPNGBDBM445689(Ex. 25/KM-06-113/(I-25) | US10683309, Example 25 |...)
Affinity DataIC50: 45nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandPNGBDBM445689(Ex. 25/KM-06-113/(I-25) | US10683309, Example 25 |...)
Affinity DataIC50: 45nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM445689(Ex. 25/KM-06-113/(I-25) | US10683309, Example 25 |...)
Affinity DataIC50: 758nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM445689(Ex. 25/KM-06-113/(I-25) | US10683309, Example 25 |...)
Affinity DataIC50: 758nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent