BDBM445673 Ex. 11/KM-06-91/(I-11)::US10683309, Example 11

SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)-c3ccc(cn3)C(F)(F)F)c2c(=O)[nH]c1=O

InChI Key InChIKey=BYPGBGBRKVMXKG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 445673   

TargetTryptophan 5-hydroxylase 1(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM445673(Ex. 11/KM-06-91/(I-11) | US10683309, Example 11)
Affinity DataIC50: 940nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
Go to US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM445673(Ex. 11/KM-06-91/(I-11) | US10683309, Example 11)
Affinity DataIC50: 76nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
Go to US Patent