BDBM445584 US10683290, Example 77

SMILES Cc1nnn(C)c1-c1cc2n([C@@H](C3CCOCC3)c3ccccc3)c3cc(cnc3c2cc1Cl)C(C)(C)O

InChI Key InChIKey=JVPYSHCVNWGQBI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 445584   

TargetBromodomain-containing protein 4 [1-477](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM445584(US10683290, Example 77)
Affinity DataIC50: 1.50E+3nMAssay Description:All assay components were dissolved in buffer composition 20 mM Hepes pH 7.5, 150 mM NaCl, 5 mM DTT, 0.005% Tween 20, and 100 ug/ml BSA for BRD4 (1-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
Go to US Patent

TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445584(US10683290, Example 77)
Affinity DataIC50: 42nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed