BDBM445479 US10683287, Example 5

SMILES [NH3+]C1=NC(CF)(COC1)c1cccc(NC(=O)c2ccc(cn2)C#N)n1

InChI Key InChIKey=ZYXUSDIABPAMMQ-UHFFFAOYSA-O

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 445479   

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM445479(US10683287, Example 5)
Affinity DataIC50: 270nMAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM445479(US10683287, Example 5)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent