BDBM445209 US10669235, Nintedanib

SMILES COC(=O)c5ccc4c(/C(=N\c2ccc(N(C)C(=O)CN1CCN(C)CC1)cc2)c3ccccc3)c(O)[nH]c4c5

InChI Key InChIKey=CPMDPSXJELVGJG-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 445209   

TargetVascular endothelial growth factor receptor 2(Human)
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US Patent
LigandPNGBDBM445209(US10669235, Nintedanib)
Affinity DataKi:  3.80nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
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Date in BDB:
2/15/2021
Entry Details
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TargetFibroblast growth factor receptor 3(Human)
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US Patent
LigandPNGBDBM445209(US10669235, Nintedanib)
Affinity DataKi:  5.90nMAssay Description:The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
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TargetPlatelet-derived growth factor receptor beta(Human)
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US Patent
LigandPNGBDBM445209(US10669235, Nintedanib)
Affinity DataKi:  8nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
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Date in BDB:
2/15/2021
Entry Details
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TargetPlatelet-derived growth factor receptor alpha(Human)
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US Patent
LigandPNGBDBM445209(US10669235, Nintedanib)
Affinity DataKi:  8.40nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
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TargetFibroblast growth factor receptor 1(Human)
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US Patent
LigandPNGBDBM445209(US10669235, Nintedanib)
Affinity DataKi:  32nMAssay Description:The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
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TargetVascular endothelial growth factor receptor 1(Human)
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US Patent
LigandPNGBDBM445209(US10669235, Nintedanib)
Affinity DataKi:  113nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent