BDBM445205 (S)-1-cyano-N-(4-(6-cyanopyridin-2-yl)-5-methylthiazol-2-yl)-N-methylpyrrolidine-2-carboxamide::US10669234, Example 144::US11319287, Example 144::US20240335427, Compound 34

SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(c(C)s1)-c1cccc(n1)C#N

InChI Key InChIKey=HHRMQBUASZODPH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 445205   

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM445205(US10669234, Example 144 | (S)-1-cyano-N-(4-(6-cyan...)
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM445205(US10669234, Example 144 | (S)-1-cyano-N-(4-(6-cyan...)
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetJosephin-1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM445205(US10669234, Example 144 | (S)-1-cyano-N-(4-(6-cyan...)
Affinity DataIC50: 2.13E+3nMAssay Description:In vitro JOSD1 activity assay was carried out with Ubiquitin-AMC assay. The Ubiquitin-AMC assay was carried out as previously described (Wernig, et a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent